Method for resolution of steroisomers in multiphase and extracti

Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...

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435183, 435177, 435179, 435180, 435182, 435135, 435136, 435148, 435155, C12P 4100

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active

048001627

ABSTRACT:
This invention relates to the resolution of racemic mixtures of optically active compounds, including but not limited to the stereochemical purification of chiral organic esters, amides, carboxylic acids, alcohols, and amines. Novel methods utilizing multiphase and extractive enzyme membrane bioreactors are disclosed that selectively produce pure or substantially purified optically active compounds from achiral precursors or mixtures of isomers in which one or several of those isomers are biologically inactive or otherwise lack desirable characteristics. There are immiscible solvents on either side of the membrane.

REFERENCES:
patent: 3907638 (1975-09-01), Uzuki et al.
patent: 4251631 (1981-02-01), Simon
patent: 4562152 (1985-12-01), Kleemann et al.
patent: 4565782 (1986-01-01), Bewick

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