Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...
Patent
1987-04-01
1989-01-24
Rosen, Sam
Chemistry: molecular biology and microbiology
Process of utilizing an enzyme or micro-organism to destroy...
Resolution of optical isomers or purification of organic...
435183, 435177, 435179, 435180, 435182, 435135, 435136, 435148, 435155, C12P 4100
Patent
active
048001627
ABSTRACT:
This invention relates to the resolution of racemic mixtures of optically active compounds, including but not limited to the stereochemical purification of chiral organic esters, amides, carboxylic acids, alcohols, and amines. Novel methods utilizing multiphase and extractive enzyme membrane bioreactors are disclosed that selectively produce pure or substantially purified optically active compounds from achiral precursors or mixtures of isomers in which one or several of those isomers are biologically inactive or otherwise lack desirable characteristics. There are immiscible solvents on either side of the membrane.
REFERENCES:
patent: 3907638 (1975-09-01), Uzuki et al.
patent: 4251631 (1981-02-01), Simon
patent: 4562152 (1985-12-01), Kleemann et al.
patent: 4565782 (1986-01-01), Bewick
Rosen Sam
Sepracor Inc.
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