Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...
Patent
1988-04-07
1991-10-15
Rosen, Sam
Chemistry: molecular biology and microbiology
Process of utilizing an enzyme or micro-organism to destroy...
Resolution of optical isomers or purification of organic...
435135, 435136, 435146, C12P 762
Patent
active
050574272
ABSTRACT:
This invention relates to a novel method of effecting aqueous enzymatic and homogeneous resolutions of racemic esters which exhibit enhanced aqueous solubility. The preferred embodiment of this invention relates to the resolutions which are effected by placing the enzyme and racemic esters in an aqueous phase wherein one of the ester enantiomers is preferentially and stereospecifically de-esterified to effect the resolution of the initial racemic mixture. In another embodiment of this invention, the resolutions are effected by placing the enzyme and racemic esters in an aqueous phase, and contacting this aqueous phase with an organic phase. The preferential and stereospecific de-esterification of one of the ester enantiomers is effected, and the chiral acid product of the de-esterification reaction is extracted into the organic phase.
REFERENCES:
patent: 4629701 (1986-12-01), Sakimae et al.
patent: 4668628 (1987-05-01), Dahod et al.
patent: 4762793 (1988-08-01), Cesti et al.
patent: 4857462 (1989-08-01), Gloger et al.
Dodds David R.
Matson Stephen L.
Wald Stephen A.
Zepp Charles M.
Rosen Sam
Sepracor Inc.
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