Method for resolution of racemic thiamphenicol precursors and in

Details Method for resolution of racemic thiamphenicol precursors and in Method for resolution of racemic thiamphenicol precursors and in

1986-12-01

1990-07-31

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564273, 564302, 564303, 564341, 564360, A61K 3110, C07C14710, C07C14712, C07C14714

Patent

active

049451812

ABSTRACT:
The present invention provides a process for the preparation of thamphenicol (I) from D,L-threo-1-(p-methylsulphonylphenyl)-2-aminopropane-1, 3-diol hydrochloride (V) and intermediates thereof. The process comprises conversion to a corresponding benzal compound followed by hydrolysis to D,L-threo-aminodiol.HCl and the following steps: ##STR1##

REFERENCES:
patent: 2726266 (1955-12-01), Piroue
patent: 2742500 (1956-04-01), Gregory et al.
patent: 2791595 (1957-05-01), Edgerton
patent: 4582918 (1986-04-01), Nagabhyshan et al.
Secor, Chem. Reviews, vol. 63, pp. 297 to 309 (1963).
Gabor et al., Chemical Abstracts, vol. 52, 1948 to 1949 (1958).
Uallonitsch et al., Chemical Abstracts, vol. 52, #20062g (1958).
Nagana et al., Chemical Abstracts, vol. 52, 307 to 308 (1958).
Rebstock et al., J. Amer. Chem. Soc., vol. 72, pp. 186 to 187 (1955).

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