Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-10-24
2006-10-24
Huff, Sheela J. (Department: 1643)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S183000, C424S094100, C424S133100
Reexamination Certificate
active
07125689
ABSTRACT:
Protein, or parts of proteins, may be rendered non-immunogenic, or less immunogenic, to a given species by identifying in their amino acid sequences one or more potential epitopes for T-cells of the given species and modifying the amino acid sequence to eliminate at least one of the T-cell epitopes. This eliminates or reduces the immunogenicity of the protein when exposed to the immune system of the given species. Monoclonal antibodies and other immunoglobulin-like molecules can particularly benefit from being de-immunised in this way: for example, mouse-derived immunoglobulins can be de-immunised for human therapeutic use.
REFERENCES:
patent: 5712120 (1998-01-01), Rodriguez et al.
patent: 0699755 (1996-06-01), None
patent: WO 9007861 (1990-07-01), None
patent: WO 9109125 (1991-06-01), None
patent: WO 9317105 (1993-09-01), None
Altuvia et al. Journal of Molecular Biology, 249:244-250, 1995.
Rammensee et al. Immunogenetics, 41:178-228, 1995.
Bruserud et al. Journal of Clinical and Laboratory Immunology 20(2):69-74, 1986.
Eyerman et al. Journal of immunology 152:1569-1577, 1994.
Adair Fiona Suzanne
Carr Francis Joseph
Carter Graham
Hamilton Anita Anne
Biovation Limited
Blanhard David J.
Huff Sheela J.
Olson & Hierl Ltd.
LandOfFree
Method for rendering streptokinase less immunogenic to a human does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for rendering streptokinase less immunogenic to a human, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for rendering streptokinase less immunogenic to a human will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3648579