Method for removing the protecting group for carboxyl group

Details Method for removing the protecting group for carboxyl group Method for removing the protecting group for carboxyl group

1993-06-17

1996-12-24

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D40312

Patent

active

055874746

ABSTRACT:
A method for removing substituted or unsubstituted allyl group from .beta.-lactam compound having substituted or unsubstituted allyl group-protecting carboxyl group, which comprises treating said .beta.-lactam compound with palladium catalyst in the presence of allyl-scavenger in aqueous organic solvent, by which the substituted or unsubstituted group can be easily and effectively removed under moderate conditions so that the desired compound can be obtained in high yield at low cost.

REFERENCES:
patent: 4174316 (1979-11-01), Christensen et al.
Journal Of Organic Chemistry; Homogenous, Palladium (0)-Catalyzed Exchange Deprotection of Allylic Esters, Carbonates, and Carbamates. 1982, vol. 47 No. 3, pp. 587-590.
Journal Of Organic Chemistry; Cepohalosporin 3'-Quinolone Esters with a Dual Mode of Action. vol. 33, No. 1, pp. 77-86.

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