Method for removing pyrogens from dialysate

Details Method for removing pyrogens from dialysate Method for removing pyrogens from dialysate

1998-05-01

2000-08-22

Fortuna, Ana

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

2105001, 2105021, 210652, 210660, 210661, 210688, 2101982, 21050027, B01D 6100

Patent

active

061067237

ABSTRACT:
A new method is described to produce large volumes of low cost water for injection directly from potable water in order to meet the needs of hemodialysis and other biological applications for ultrapure water. The source water is processed by a combination of membrane and chromatographic methods including reverse osmosis, ion exchange deionization, endotoxin-specific adsorption steps and polishing filtration to reduce contaminant levels below those specified by the US Pharmacopoiea. Endotoxin removal from dialysate was demonstrated. The endotoxin removing adsorbent also adsorbs LAL-negative pyrogens from the test samples.

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