Method for removing N-terminal methionine

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 694, 435 6952, 530300, 530311, 530331, 530343, 530350, 530351, 530399, C12P 2106, C07K 1107, C07K 112

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active

060664703

ABSTRACT:
The present invention provides a method for chemically removing a N-terminal methionine residue selectively, specifically and efficiently from a peptide or a salt thereof having an optionally oxidized methinine residue at its N-terminal. The method reacts a peptide or a salt thereof having an optionally oxidized methinine residue at its N-terminal with an .alpha.-diketone derivative, followed by hydrolysis.

REFERENCES:
Abstract for EP 97 30 3856, dated Sep. 30, 1997, included in European Search Report.
Derwent AN 95-038217 to JP 06 316 557 Nov. 15, 1995.
Caplus Abstract No. 1995: 380330 of JP06316557 Nov. 15, 1994 with Displayed Structures from Reg No.

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