Method for removing high boiling solvents from drug formulations

Details Method for removing high boiling solvents from drug formulations Method for removing high boiling solvents from drug formulations

1997-01-31

2000-04-04

Lee, Howard C.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

203 56, 203 57, 203 63, 203 73, 536127, A61K 900, C07H 106, B01D 300

Patent

active

060458089

ABSTRACT:
A method for removing a high boiling solvent from a pharmaceutical composition dissolved in the high boiling solvent comprising adding a low boiling co-solvent to the solution to form a mixture of the high boiling solvent and the low boiling co-solvent, and removing the solvent/co-solvent mixture under vacuum.

REFERENCES:
patent: 3532677 (1970-10-01), Baron et al.
Laskar et al., "Degradation of Carmustine in Mixed Solvent and Nonaqueous Media", Journal of Pharmaceutical Sciences, vol. 66(8): 1076-1078, Aug. 1977.
Mark, H.F., et al.: "Kirk-Othmer Encyclopedia of Chemical Technology, Supplement Volume: Alcohol Fuels to Toxicology, Edition 3, " 1989, Wiley & Sons, US, New York, pp. 145-158.
PCT International Search Report:PCT/US98/00034.

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