Method for removal of human antibodies to native DNA from serum

Details Method for removal of human antibodies to native DNA from serum Method for removal of human antibodies to native DNA from serum

1983-11-30

1987-09-01

Nucker, Christine M.

Chemistry: analytical and immunological testing

For preexisting immune complex or auto-immune disease

Antinuclear

210635, 210656, 210927, 4351722, 436529, 436538, 436540, 436542, 436545, 436548, 436811, 436824, 530387, 530813, 530808, 935108, 935110, G01N 33564, G01N 33577

Patent

active

046909052

ABSTRACT:
The invention relates to monoclonal anti-idiotypic antibodies to human anti-DNA antibodies. Monoclonal, anti-idiotypic antibodies are produced using hybridoma technology. The antibodies are used as diagnostic reagents in methods to determine the presence of anti-native DNA antibodies in serum from patients suspected of having systemic lupus erythematosus, and as therapeutic reagents in methods to remove the anti-native DNA antibodies from the serum of patients with systemic lupus erythematosus.

REFERENCES:
patent: 4490290 (1984-12-01), Gani et al.
patent: 4493899 (1985-01-01), Smith et al.
patent: 4544640 (1985-10-01), Soma et al.
Kohler, G., and Milstein, C., Nature, vol. 256, 495-497 (1975).
Andrzejewski, C., Rauch, J., Lafer, E., Stollar, B. D., and Schwartz, R. S., Journal of Immunology, vol. 126, 226-231 (1981).
Abdov, N. I., Wall, H., Lindsley, H. B., Halsey, J. F., and Suzuki, T., Journal of Clinical Investigation, vol. 67, 1297-1304 (1981).
Joyce Rausch et al., "A High Frequency Idiotypic Mark etc", The Journal of Immunology, vol. 129, No. 1, Jul. 1982.
Betty Diamond et al., "Reactivity of Monoclonal Anti Idiotype etc", Biological Abstracts/RRM No. 26051813, from Clin. Res., vol. 31, No. 2, p. 520 A, 1983.
G. A. Solomon et al., "The Use of Mono Clonal Anti Idiotypic etc", Biological Abstracts RRM, No. 26023959, from Clin. Res., vol. 31, No. 1, p. 161A, 1983.

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