Method for relieving chronic pain with a somatostatin analog com

Details Method for relieving chronic pain with a somatostatin analog com Method for relieving chronic pain with a somatostatin analog com

1989-06-20

1991-04-09

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

A61K 3702

Patent

active

050065106

ABSTRACT:
A particularly preferred peptide has the amino acid sequence ##STR1## and is combined with a carrier effective to promote passage of the peptide through a patient's skin for an antinociceptive composition useful for relieving pain in a patient experiencing burning pain or hyperesthesia. Topical application of the composition has been found dramatically to reduce such pain in most individuals treated for periods of from about 5-24 hours, and continued control of the pain can be had by daily doses.

REFERENCES:
patent: 3981996 (1976-09-01), Leigh
patent: 4091090 (1978-05-01), Tibor
patent: 4395403 (1983-06-01), Bauer et al.
patent: 4496543 (1985-01-01), Bauer et al.
Weber et al., Surgery, vol. 102(6), pp. 974-981.
M. Matucci-Cerinic, M.D. et al., "Somatostatin Treatment of Psoriatic Arthritis", Jan.-Feb. 1988, pp. 56-58, International Journal of Dermatology, vol. 27, No. 1.
Sandostatin.RTM. octreotide acetate/SANDOZ Injection--Product insert, pp. 1-2, Columns 1-4, 1989 Sandoz Pharmaceuticals Corporation.

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