Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-03-25
1993-07-20
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514659, A61K 31135, A61K 31405
Patent
active
052294129
ABSTRACT:
Compounds that selectively bind 5-HT.sub.1A receptors in preference to other 5-HT receptors are provided along with methods for their use. Such compounds have the formula ##STR1## wherein A is an aromatic group selected to provide, with the glycidyl residue that forms the next portion of the molecule, a 5-HT-like portion of the molecule that represents the primary binding site of the molecule with a 5-HT receptor: X represents a quarternary carbon and its attached alkyl groups: Y represents a hydrocarbon linking group: Z represents hydrogen or an organic group containing up to 12 carbon and/or heteroatoms in its skeletal structure: and R.sup.1 and R.sup.2 independently represent hydrogen or an alkyl group. The aromatic group is most preferably indole or an indole derivative.
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Peroutka Stephen J.
Pitha Josef
Grimes Eric
Neeley Richard L.
The Board of Trustees of the Leland Stanford Junior University
Wax Robert A.
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