Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-04-28
1997-04-15
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
424 45, A61K 31415, A61L 904
Patent
active
056210078
ABSTRACT:
Methods for the therapy of cystic fibrosis and multi-drug resistance in cancer chemotherapy by administering to a patient in need thereof 5-trifluoroethyl-1-(5-chloro-2-hydroxyphenyl)-1,3-dehydro-2H-benzimidazol- 2-one (NSOO4) or a pharmaceutically acceptable salt thereof.
REFERENCES:
patent: 5100647 (1992-03-01), Agus et al.
patent: 5200422 (1993-04-01), Olesen et al.
Cotton, C.U., et al., J. Clin. Invest., 79: 80-85 (1987).
Welsh, M.J., FASEB J., 4: 2718-2725 (1990).
Rommens, J.M., et al., Science, 245: 1059-1065 (1989).
Riordan, J.R., et al., Science, 245: 1066-1072 (1989).
Bear, C., et al., J. Biol. Chem., 266: 19142-19145 (1991).
Higgins, C.F., Ann. Rev. Cell Biol., 8: 67-113 (1992).
Hyde, S.C., et al., Nature, 346: 362-365 (1990).
Gabriel, S.E., et al., Nature, 363: 263-266 (1993).
Collins, F.S. Science, 256: 774-779 (1992).
Kerem, B.S., et al., Science, 245: 1073-1080 (1989).
Dalemans, W., et al., Nature, 354: 526-528 (1991).
Drumm, M.L., et al., Science, 254: 1797-99 (1991).
Gill, D.R., et al., Cell, 71: 23-32 (1992).
Valverde, M.A., et al., Nature, 355: 830-833 (1992).
Dworetzky Steven I.
Gribkoff Valentin K.
Temple Davis L.
Bristol--Myers Squibb Company
Goldberg Jerome D.
LandOfFree
Method for regulation of transmembrane chloride conductance does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for regulation of transmembrane chloride conductance, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for regulation of transmembrane chloride conductance will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-361187