Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2005-07-19
2005-07-19
Guzo, David (Department: 1636)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S320100, C536S023100, C536S023200, C536S024100, C514S04400A
Reexamination Certificate
active
06919207
ABSTRACT:
A non-invasive method for gene regulation during gene therapy comprises the steps of introducing electromagnetic field response elements into a gene promoter not having any electromagnetic field response elements to serve as switches for regulating exogenously introduced genes, and applying an electromagnetic field to the introduced electromagnetic field response elements to induce gene expression. In this way, a safer, more effective, and more precise method for gene therapy is provided of inducing production of desired genetic products.
REFERENCES:
Tofani et al. Static and ELF magnetic fields induce tumor growth inhibition and apoptosis. Bioelectromagnetics. Sep. 2001;22(6):419-28.
DiCarlo et al. A simple experiment to study electromagnetic field effects: protection induced by short-term exposures to 60 Hz magnetic fields. Bioelectromagnetics. 1998;19(8):498-500.
Kapturczak et al. Curr Mol Med. May 2001;1(2):245-58.
Collateral Therapeutics, Inc. (Public release) at http://www.eurekalert.org/pub_release/2001-12/ct-nrol12601.php.
Arnone et al. The hardwiring of development: organization and function of genomic regulatory systems. Development. May 1997;124(10):1851-64.
Blank et al. Electromagnetic initiation of transcription at specific DNA sites. J Cell Biochem. 2001;81(4):689-92.
Campbell et al. Adenovirus-mediated p16INK4 gene transfer significantly suppresses human breast cancer growth. Cancer Gene Ther. Sep. 2000;7(9):1270-8.
Lin et al. A magnetic field-responsive domain in the human HSP70 promoter. J Cell Biochem. Oct. 1, 1999;75(1):170-6.
Lin et al. Magnetic field activation of protein-DNA binding. J Cell Biochem. Sep. 1, 1998;70(3):297-303.
Lin et al. Myc-mediated transactivation of HSP70 expression following exposure to magnetic fields. J Cell Biochem. May 1, 1998;69(2):181-8.
Tomiyasu et al. Direct intra-cardiomuscular transfer of beta2-adrenergic receptor gene augments cardiac output in cardiomyopathic hamsters. Gene Ther. Dec. 2000;7(24):2087-93.
Zang et al. Adenovirus 5 E1a-mediated gene therapy for human ovarian cancer cells in vitro and in vivo. Int J Gynecol Cancer. Jan.-Feb. 2001;11(1):18-23.
Rosengart et al. Six-month assessment of a phase I trial of angiogenic gene therapy for the treatment of coronary artery disease using direct intramyocardial administration of an adenovirus vector expressing the VEGF121 cDNA. Ann Surg. Oct. 1999;230(4):466.
Navarro et al. Efficient gene transfer and long-term expression in neurons using a recombinant adenovirus with a neuron-specific promoter. Gene Ther. Nov. 1999;6(11):1884-92.
Park et al. Therapeutic levels of human factor VIII and IX using HIV-1-based lentiviral vectors in mouse liver. Blood. Aug. 1, 2000;96(3):1173-6.
Kon et al. Naked plasmid-mediated gene transfer to skeletal muscle ameliorates diabetes mellitus. J Gene Med. May-Jun. 1999;1(3):186-94.
Hana Lin et al Specific Region of the c-myc Promoter is Responsive to Electric and Magnetic Fields Journal of Cellular Biochemistry 54:281-288(1994).
Li Han etal Application of Magnetic Field-Induced Heat Shock Protein 70 for Presurgical Cytoprotection Journal of Cellular Biochemistry 71:577-583(1998).
Hana Lin etal Regulating Genes with Electromagnetic Response Elements Journal of Celluar Biochemistry 81:143-148 (2001).
Ming Jin etal Biological and technical variables in myc expression in HL60 cells exposed to 60 Hz electromagnetic fields Bioelectrochem Bioenerg Vo; 44 No 1 pp. 111-120.
Marshall, E. Gene therapy's growing pains. Science. Aug. 25, 1995;269(5227):1050, 1052-5.
Junkersdorf et al. Electromagnetic fields enhance the stress response at elevated temperatures in the nematodeCaenorhabditis elegans. Bioelectromagnetics. Feb. 2000;21(2):100-6.
Wang et al. Sustained expression of therapeutic level of factor IX in hemophilia B dogs by AAV-mediated gene therapy in liver. Mol Ther. Feb. 2000;1(2):154-8.
Ross et al. Gene therapy in the United States: a five-year status report. Hum Gene Ther. Sep. 10, 1996;7(14):1781-90.
Verma et al. Gene therapy—promises, problems and prospects. Nature. Sep. 18, 1997;389(6648):239-42.
Rux et al. Type-specific epitope locations revealed by X-ray crystallographic study of adenovirus type 5 hexon. Mol Ther. Jan. 2000;1(1):18-30.
Orkin et al. Report and recommendations of the panel to assess the NIH investment in research on gene therapy. Dec. 7, 1995, available through NIH or at http://www.nih.gov
ews/panelrep. html.
Jindal et al. Prevention of diabetes in the NOD mouse by intra-muscular injection of recombinant adeno-associated virus containing the preproinsulin II gene. Int J Exp Diabetes Res. 2001;2(2):129-38.
Ye et al. Regulated delivery of therapeutic proteins after in vivo somatic cell gene transfer. Science. Jan. 1, 1999;283(5398):88-91.
Edelberg et al. Enhancement of murine cardiac chronotropy by the molecular transfer of the human beta2 adrenergic receptor cDNA. J Clin Invest. Jan. 15, 1998;101(2):337-43.
Edelberg et al. Molecular enhancement of porcine cardiac chronotropy. Heart. Nov. 2001;86(5):559-62.
Steiner et al. Antisense c-myc retroviral vector suppresses established human prostate cancer. Hum Gene Ther. Mar. 20, 1998;9(5):747-55.
Huang et al. [Using Hsp70 promoter to regulate target gene expression in tumor] Zhonghua Bing Li Xue Za Zhi. Jun. 2001;30(3):198-201.
Madio et al. On the feasibility of MRI-guided focused ultrasound for local induction of gene expression. J Magn Reson Imaging. Jan.-Feb. 1998;8(1):101-4.
Okano et al. Modulatory effects of static magnetic fields on blood pressure in rabbits. Bioelectromagnetics. Sep. 2001;22(6):408-18.
Blank, M. et al. Electromagnetic fields may act directly on DNA. Journal of Cellular Biochemistry. 1999, vol. 75, pp. 369-374.
Lin et al. Electromagnetic field exposure induces rapid, transitory heat shock factor activation in human cells. Journal of Cellular Biochemistry. 1997, vol. 66, pp. 482-488.
Goodman, R. et al. Magnetic field stress induces expression of hsp70. Cell Stress Chaperones. 1998, vol. 3, No. 2, pp. 79-88.
Blank Martin
Goodman Reba
Lin Hana
Cooper & Dunham LLP
Guzo David
Sullivan Daniel M.
The Trustees of Columbia University in the City of New York
White, Esq. John P.
LandOfFree
Method for regulating genes with electromagnetic response... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for regulating genes with electromagnetic response..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for regulating genes with electromagnetic response... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3418617