Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1994-09-26
1998-09-29
Cunningham, Thomas M.
Drug, bio-affecting and body treating compositions
Lymphokine
424 852, 4241851, 514 12, 514 21, 530351, 530395, A61K 3818, C07K 1454
Patent
active
058143076
ABSTRACT:
The present invention relates to methods of using oncostatin M (OM). In particular, it relates to the use of OM to stimulate interleukin 6 (IL-6) synthesis in target cells, especially human endothelial cells. The resultant IL-6, in turn, may perform a variety of functions such as cell growth regulation, leukocyte differentiation, and tumor inhibition. Furthermore, the present invention also relates to the use of OM to treat cytopenias, including anemia and thrombocytopoiesis, and to increase tolerance to irradiation and cytotoxic drugs. Therefore, the methods of the invention may have a wide range of applications, including, but not limited to, the inhibition of tumor growth, the treatment of cytopenias, and to increase the tolerance to radio- and chemotherapy. OM may be used in combination with various cytokines, including erythropoietin, colony-stimulating factors, interleukin-3 or thrombopoietin.
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Brown Thomas J.
Wallace Philip M.
Bristol--Myers Squibb Company
Cunningham Thomas M.
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