Method for regulating bone metabolism of warm-blooded animals, a

Details Method for regulating bone metabolism of warm-blooded animals, a Method for regulating bone metabolism of warm-blooded animals, a

1981-08-31

1982-12-21

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

A61K 3159

Patent

active

043649416

ABSTRACT:
A method for regulating the bone metabolism of a warm-blooded animal, which comprises administering pharmaceutically effective amounts of 1.alpha., 24-dihydroxycholecalciferol (1.alpha., 24-DHCC) and 24,25-dihydroxycholecalciferol (24,25-DHCC) to said warm-blooded animal, and a pharmaceutical composition comprising 1.alpha.,24-DHCC, 24,25-DHCC and a pharmaceutically acceptable carrier.
According to the invention, a condition of abnormal bone metabolism requiring long-term therapy, such as osteoporosis, can be safely treated by administering 1.alpha., 24-DHCC and 24,25-DHCC over a long period of time because no substantial adverse effect of 1.alpha., 24-DHCC on the metabolis of 24,25-DHCC is observed.

REFERENCES:
patent: 4021423 (1977-05-01), Baggiolini et al.
patent: 4022891 (1977-05-01), Takeshita et al.
patent: 4305935 (1981-12-01), Kawashima et al.
Chem. Abstracts, vol. 91 (1979) Par. 598(e), Abstract of an article by Lieberheer et al.
Chem. Abstracts, vol. 90 (1979) Par. 70.874, Abstract of an article by Queille et al.

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