Method for regenerating corneal epithelium

Details Method for regenerating corneal epithelium Method for regenerating corneal epithelium

1982-09-30

1984-10-16

Rosen, Sam

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

A61K 3512

Patent

active

044774354

ABSTRACT:
A composition and a method for regenerating wounded or damaged corneal epelium are described. The composition comprises an aqueous solution containing an effective amount of ocular extract RE. The RE is extracted from eye tissues, such as choroid, iris and vitreous as well as aqueous humor. The active extract is obtained by the treatment of bovine ocular tissues with a buffered aqueous saline solution at pH of about 7.2. For ophthalmological use, the RE extract is purified by precipitation with acetic acid and dialyzed against physiologic saline NaCl solution. Such a composition is shown to increase significantly the rate of healing of wounded corneal epithelium.

REFERENCES:
Kishimoto et al., Acta. Soc. Ophthal. Japan, vol. 68, pp. 1145-1158.
Arruti et al., Experimental Cell Research, vol. 117 (1978), pp. 283-292.

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