Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-12-11
2007-12-11
Kemmerer, Elizabeth C. (Department: 1649)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C530S408000
Reexamination Certificate
active
10276358
ABSTRACT:
The present invention relates to novel methods for making and refolding insoluble or aggregated proteins having free cysteines in which a host cell expressing the protein is exposed to a cysteine blocking agent. The soluble, refolded proteins produced by the novel methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form PEGylated proteins.
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Cox George N.
Doherty Daniel H.
Rosendahl Mary S.
Bolder Biotechnology Inc.
Borgeest Christina
Kemmerer Elizabeth C.
Sheridan & Ross P.C.
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