Method for reducing toxic effects of methyl-glyoxal bis-guanylhy

Details Method for reducing toxic effects of methyl-glyoxal bis-guanylhy Method for reducing toxic effects of methyl-glyoxal bis-guanylhy

1982-08-24

1985-05-28

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

A61K 31155

Patent

active

045200319

ABSTRACT:
A method of treating cancers or advanced malignant disease involving the weekly administration of methyl-glyoxal bis-guanylhydrazone in amounts of 250-1,000 mg/m.sup.2 per week. In particular the administration involves a weekly dosing regimen and dose escalation over the series of treatments from an initial dosage which may be 250 mg/m.sup.2.

REFERENCES:
Boiron et al., Cancer Chemotherapy Reports No. 45, Apr., 1965, pp. 69-73.
Knight, III et al., Cancer Treatment Reports, vol. 63, No.-11-12, Nov./Dec. 1979, pp. 1933-1937.

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