Method for reducing the risk of atherosclerosis

Surgery – Blood drawn and replaced or treated and returned to body

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604 5, A61M 3700

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active

052795403

ABSTRACT:
A method for reducing the risk of atherosclerosis in a patient at risk of same comprising the steps of removing cholesterol ester transfer protein from blood of the patient to reduce the plasma CETP levels in the patient. In an embodiment, the method includes the step of passing the patient's plasma through an apheresis machine to remove at least some of the plasma cholesterol ester transfer protein.

REFERENCES:
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patent: 4923439 (1990-05-01), Seidel et al.
"Plasma High Density Lipoprotein is Increased in Man when LDL is Lowered by LDL Pheresis" Parker et al., Proceedings, Natl. Academy of Sciences, vol. 83, pp. 777-781, Feb. 1986.
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Yamashita et al, Accumulation of Apolipoprotein E-rich High Density Lipoproteins in Hyperalphalipoproteinemic Human Subjects with Plasma Cholesteryl Ester Transfer Protein Deficiency, J. Clin. Invest., vol. 86, 9-90, 688-695.
Hesler et al, Structure-Function Analysis of Plasma Cholesteryl Ester Transfer Protein by Protease Digestion and Expression of cDNA Fragments in Escherichia coli, The Journal of Biological Chemistry, vol. 264, No. 19, Issue of Jul. 5, 1989, pp. 11317-11325.
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Horwitz, Apheresis Adsorbs LDL Only, Medical Tribune, date unknown.

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