Method for reducing the occurrence of distal anastomotic intimal

Details Method for reducing the occurrence of distal anastomotic intimal Method for reducing the occurrence of distal anastomotic intimal

1987-10-21

1989-06-20

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 21, 623 1, A61K 3170

Patent

active

048409405

ABSTRACT:
A method is provided for reducing the occurrence of anastomotic intimal hyperplasia in grafts of artery, vein, biologic or synthetic conduits having end-to-side distal anastomosis. The method includes administering a regimen of fractionated heparin to the subject. Administration of the fractionated heparin can be either intravenously, intraperitoneally, subcutaneously or orally. Preferred dosage is 50-80 mg./kg. body weight per day.

REFERENCES:
patent: 4503568 (1985-03-01), Madras
patent: 4546499 (1985-10-01), Possis et al.
patent: 4717719 (1988-01-01), Sportoletti et al.

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