Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
2000-12-21
2003-08-19
Dees, Jose′ G. (Department: 1616)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C514S724000, C514S727000, C514S740000, C514S844000
Reexamination Certificate
active
06607735
ABSTRACT:
FIELD OF THE INVENTION
This invention relates to compositions and methods for treating the skin under they eyes of mammal. More particularly, it relates to compositions containing at least one compound selected from an alkanolamine and/or tyrosine and their application to mammalian skin. The compositions can be applied to skin to effect a reduction in the puffiness of skin under the eyes and the appearance of dark circles around the eyes, in particular, under the eyes.
BACKGROUND OF THE INVENTION
Human beings have long sought products that can enhance the appearance of the skin and reduce the signs of stress and aging without cosmetic surgery. The skin around the eye is relatively thin and contains less fat than most other areas of skin. For this reason, a widespread cosmetic problem is the appearance of puffy or pouch-like skin, bags, rings or dark circles beneath the eyes. These conditions can be caused by stress, lack of sleep, overindulgence with alcohol, aging, various diseases, and other environmental factors that irritate the eyes and the surrounding skin.
It is believed that the dark circles on the skin around the eye is a result of temporary blood pooling or stasis which is exacerbated at night when lying prone when the blood vessels around the eye are subjected to higher blood pressure relative to an upright (daytime activity) posture. Overnight, the blood in the venous side of the circulatory system pools in the rich vascular bed under the eye due to the higher resistance to flow when prone, resulting in a dark appearance of the area under the eye particularly evident upon rising in the morning. Most products designed for treating dark circles are tinted with pigments of various colors to cover over or offset the dark of the dark circles and reflect incident light. They merely cover the existing dark circles. Another approach is to use products containing cell stimulants such as retinoids to attempt to thicken the skin over the area to hide the darker blood rich skin beneath. Such products require weeks to become effective, and are often irritating to the sensitive skin around the eyes.
Thus, it is an object of this invention to provide topical compositions that can be used to ameliorate puffiness and improve the appearance of dark circles of mammalian skin surrounding the eyes immediately (within 30-60 minutes) after application.
It is another object of this invention is to provide topical compositions to ameliorate puffiness and the appearance of dark circles that is well-tolerated by the skin.
SUMMARY OF THE INVENTION
It has been discovered that compositions containing at least one compound selected from an alkanolamine can be used to alleviate the puffiness and dark circles of mammalian skin, in particular skin around the eyes.
Accordingly, in one embodiment, the invention relates to a method treating the skin around the eyes of a mammal, said method comprising topically applying to the skin a composition comprising an effective amount of at least one alkanolamine. The alkanolamine has the following general formula:
wherein X, Y and Z are selected from the group consisting of hydrogen, C
1
-C
3
alkyl group, C
2
-C
4
alkanol group, wherein at least one of X, Y or Z is a C
2
-C
4
alkanol group bearing at least one hydroxyl group and optionally at least one carboxyl group.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
As discussed above, the invention relates to a method for treating the skin around the eyes, in particular, the skin under the eyes. In particular, the invention relates to a method for reducing the appearance of dark circles and puffiness of the skin around the eye. The method comprises topically applying to the affected skin area, a composition comprising an effective amount of at least one alkanolamine. The alkanolamine has the following general formula:
wherein X, Y and Z are selected from the group consisting of hydrogen, C
1
-C
3
alkyl group, C
2
-C
4
alkanol group, wherein at least one of X, Y or Z is a C
2
-C
4
alkanol group bearing at least one hydroxyl group and optionally at least one carboxyl group.
In a preferred embodiment the alkanolamine is selected from the group consisting of ethylaminoethanol, methylaminoethanol, dimethylaminoethanolamine, isopropanolamine, triethanolamine, isopropanoldimethylamine, ethylethanolamine, 2-butanolamine, choline and serine. More preferably, the alkanolamine is dimethylaminoethanol (DMAE).
The compositions used in the methods according to the invention preferably contain from about 0.1 about 10% by weight of the at least one alkanolamine, more preferably, from about 0.1 to about 5% and, most preferably, from about 1 to about 3% by weight.
In a preferred embodiment, the compositions used in the methods of the invention contain a pH buffering agent. Preferably, the amount of buffering agent should be that which would result in compositions having a pH ranging from about 4.5 to about 8.5, more preferably from about 5.5 to about 8.5, most preferably from about 6.5 to about 8.0. The buffering agent can be any of the known buffering agents commonly found in cosmetic compositions provided that they are physically and chemically stable with the other ingredients of the composition. Suitable buffering agents include organic acids such as (but not intended to be restricted to) citric acid, malic acid, and glycolic acid.
Another compound which is advantageously present in the compositions of this invention is tyrosine. Tyrosine may be present in the compositions of this invention in the amount of from about 0.01 to about 5%, more preferably from about 0.04 to about 3% by weight and most preferably about 0.5% by weight, based on the total composition.
The compositions of this invention should be in the form of topical products that can be applied externally to the skin and can be prepared in accordance with conventional techniques known to those of ordinary skill in the art. The carrier may take a variety of physical forms such as, for example, creams, dressings, gels, lotions, ointments or liquids, including leave on and rinse-off compositions, as well as incorporated into material carriers such as dry or wet wipes, puffs, hydro-gel matrixes, or adhesive (or non-adhesive) patches by means known in the art. Preferably, the carrier should be a gel or moisturizing lotion, a cooling solution, or in the form of a dry or wet wipe. One could also utilize this in a convenient spray applicator.
Typical carriers include lotions containing water and/or alcohols and emollients such as hydrocarbon oils and waxes, silicone oils, hyaluronic acid, vegetable, animal or marine fats or oils, glyceride derivatives, fatty acids or fatty acid esters or alcohols or alcohol ethers, lanolin and derivatives, polyhydric alcohols or esters, wax esters, sterols, phospholipids and the like, and generally also emulsifiers (nonionic, cationic or anionic), although some of the emollients inherently possess emulsifying properties. These same general ingredients can be formulated into a cream rather than a lotion, or into gels, or into solid sticks by utilization of different proportions of the ingredients and/or by inclusion of thickening agents such as gums or other forms of hydrophillic colloids. Such compositions are referred to herein as cosmetically acceptable carriers. Preferably, the carrier should be a gel base formula without lipid materials that would exxacerbate the oiliness of acne prone skin. However, a moisturizer emulsion base may be preferred by individuals that have particularly dry yet skin still suffer from acne lesions.
The topical compositions according to the invention can comprise additional ingredients commonly found in skin care compositions, such as for example, emollients, skin conditioning agents, emulsifying agents, humectants, preservatives, antioxidants, perfumes, chelating agents, etc., provided that they are physically and chemically compatible with the other components of the composition. It is also envisioned that this invention could be combined with other agents such as topical anesthetics (such as
Cole Curtis
Ganopolsky Irina
Dees Jose′ G.
Harriman Erin M.
Johnson & Johnson Consumer Companies Inc.
Lamm Marina
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