Method for reducing sickle erythrocyte dehydration and delaying

Details Method for reducing sickle erythrocyte dehydration and delaying Method for reducing sickle erythrocyte dehydration and delaying

1993-11-18

1995-08-15

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142358, 514397, A61K 31495, A61K 3138, A61K 31415

Patent

active

054419573

ABSTRACT:
The present invention provides a chemical class of active compounds to be used as efficacious drugs in the treatment of sickle cell disease. The active compounds include imidazole derivatives, nitroimidazole derivatives, and triazole derivatives. These compounds are to be administered by any preferred route of administration including oral, intramuscular, intravenous, and any other parenteral route. If desired, these drugs may also be administered transmucosally, or subcutaneously, or using a dermal patch on the skin. In addition, the methodology is effective for both long term and short term therapy; may be employed prophylactically and/or therapeutically; and may be used in emergency, acute crisis clinical situations.

REFERENCES:
patent: 4343808 (1982-08-01), Broersma et al.
patent: 4696937 (1987-09-01), Sebille et al.
Speight (Editor), Avery's Drug Treatment, 3rd edition, 1987, p. 1005.

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