Method for reducing serum lipoprotein (A) concentration

Details Method for reducing serum lipoprotein (A) concentration Method for reducing serum lipoprotein (A) concentration

1998-05-19

1999-06-22

Patterson, Jr., Charles L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

514 12, 424450, A61K 3100

Patent

active

059143118

ABSTRACT:
A method of reducing serum Lp(a) concentration in a subject is accomplished by administration of liposomes. A suspension of small, unilamellar vesicles composed primarily of phosphatidylcholine phospholipids is administered parenterally to a subject having or at risk for developing a disease condition associated with an elevated serum Lp(a) concentration. The liposomes are infused over a period of time such that a significant drop in serum Lp(a) concentration is observed.

REFERENCES:
patent: 4812314 (1989-03-01), Barenholz et al.
patent: 5741514 (1998-04-01), Barenholz et al.
Davidson et al. (Jul., 1995) "Effects of Acceptor Particle Size on the Efx of Cellular Free Cholesterol" J. Biol. Chem. 270/29, pp. 17106-13.
DeLamatre et al. (1986) "Role of Apolipoproteins in cellular efflux" Biochimica et Biophys. Acta 875, pp. 419-428.

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