Method for reducing pain associated with the administration of 4

Details Method for reducing pain associated with the administration of 4 Method for reducing pain associated with the administration of 4

1985-03-22

1988-09-13

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

514105, A61K 3166

Patent

active

047708700

ABSTRACT:
Through the combined use of a 4-sulfido-oxazaphosphorine of the formula: ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are hydrogen, methyl, ethyl, 2-chloroethyl or 2-methanesulfonyloxyethyl and at least two of them are taken from the group consisting of 2-chloroethyl and 2-methanesulfonyloxyethyl, R.sub.4 is hydrogen or methyl, R.sub.5 is a C.sub.2 -C.sub.6 -hydroxyalkyl group or a C.sub.2 -C.sub.6 -mercaptoalkyl group of each of these groups with an additional mercapto group, or R.sub.5 is a carboxy-C.sub.1 -C.sub.10 alkyl group, a carb-C.sub.1 -C.sub.6 -alkoxy-C.sub.1 -C.sub.10 -alkyl group, a 2-amino-2-carboxyethyl group, a 2-amine-2-carb-C.sub.1 -C.sub.6 -alkoxy-ethyl group, a 2-C.sub.2 -C.sub.6 -alkanoylamino-2-carboxyethyl group, the glutathionyl group, a C.sub.2 -C.sub.6 -sulfoalkyl group or a C.sub.2 -C.sub.6 -sulfoalkyl group which contains a mercapto group or a physiologically compatible salt thereof in combination with a thion compound of the formula:

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