Method for reducing intraocular pressure in the mammalian eye by

Details Method for reducing intraocular pressure in the mammalian eye by Method for reducing intraocular pressure in the mammalian eye by

1994-11-30

1996-09-24

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514569, 514737, 514516, 514912, 514913, 424 7804, A61K 31195

Patent

active

055591515

ABSTRACT:
Pharmaceutical compositions and a method are disclosed for treating glaucoma and/or ocular hypertension in the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains, as the active ingredient, one or more compounds having chloride channel blocking activity. Examples of chloride channel blockers utilized in the pharmaceutical composition and method of treatment are: ##STR1## wherein R is hydrogen or a pharmaceutically-acceptable cation, e.g. an alkali or alkaline earth metal, or a quaternary amine; or R represents a ester-forming moiety, e.g. a lower alkyl radical, having up to six carbon atoms, that may be derived from a lower alkanol.

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T. L. Lewis and C. L. Chronister. Etiology and pathophysiology of primary open-angle glaucoma. In: Primary Care of the Glaucomas. T. L. Lewis and M. Fingeret, Editors. Appleton and Lance Publishers. 1993:65-80.
W. M. Hart. Intraocular Pressure. In: Adler's Physiology of the Eye. W. M. Hart, Editor. Mosby Year Book, Publisher. 1992: 248-267.
R. F. Brubaker. The physiology of aqueous humor formation. In: Glaucoma: Applied Pharmacology in Medical Treatment. S. M. Drance and A. H. Neufeld, Editors, Harcourt Brace Jovanovich, Publishers. 1984:35-70.
Biochimica et al Biophysica Acta, vol. 947, 1988, pp. 521-547, Gogelein, H., "Chloride channels in epithelia".
American Physiological Society, 1994, vol. 0363-6143, pp. C1210-C-1221, Edelman et al., "Ion transport asymmetry and functional coupling in bovine pigmented and nonpigmented ciliary epithelial cells".
Acta Physiol Scand: No. 149, 1993: pp. 365-376, Fryklund et al., "The effects of chloride transport inhibitors on intestinal fluid and ion transport in vivo and in vitro".

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