Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1995-07-28
1999-04-06
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514912, A61K 3123
Patent
active
058919112
ABSTRACT:
Pharmaceutical compositions and a method are disclosed for treating glaucoma and/or ocular hypertension in the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains as the active ingredient one or more compounds having calcium chelating activity. Examples of calcium chelating agents utilized in the pharmaceutical composition and method of treatment are: ##STR1## and lower alkyl and alkoxyalkyl esters thereof.
REFERENCES:
patent: 3467756 (1969-09-01), Stone
patent: 4197301 (1980-04-01), Smith et al.
patent: 4565821 (1986-01-01), Chiou
patent: 4886815 (1989-12-01), Schachar
patent: 5066664 (1991-11-01), Poli et al.
patent: 5091528 (1992-02-01), Gluchowski
patent: 5260059 (1993-11-01), Acott et al.
patent: 5380303 (1995-01-01), Holly et al.
Schlaepfer et al, Neurochemical Research, vol. 6, No. 3, 1981, Calcium-Mediated Breakdown of Glial Filaments and Neurofilaments in Rat Optic Nerve and Spinal Cord, pp. 243-255.
Tymianski et al, Neuron, vol. 11, Aug. 1993, Cell-Permanent Ca2- Chelators Reduce Early Excitotoxic and Ischemic Neuronal Injury In Vitro and In Vivo, pp. 221-235.
Robert E. Kennedy, Transactions of the Americal Ophthalmological Society, vol. LXXII, 1974, Further Observations On Atypical Band Keratopathy In Glaucoma Patients, pp. 107-122.
Thomas J. Zimmerman, Annals of Ophthalmology, vol. 11, No. 5, May 1979, Medical Trabeculocanalotomy In Monkeys With Cytochalasin B or EDTA, pp. 795-796.
Anders Bill, Upsala Journal of Medical Sciences, vol. 85, No. 3, 1980, Effects of Na2EDTA and Alpha-Chymotrypsin On Aqueous Humor Outflow conductance in Monkey Eyes.
Bill et al, Investigative Ophthalmology & Visual Science, vol. 19/5, May 1980, Effects of intrcameral Na2EDTA and EGTA on Aqueous Outflow routes in the Monkey Eye, pp. 492-504.
Richard P. Haugland, Molecular Probes; Handbook of Fluorescent Probes and Research Chemicals, 1992-1994; Set 20: Calcium Indicators, Chelators and Inonphores, pp. 113-120.
Adorante Joseph S.
Ruiz Guadalupe
WoldeMussie Elizabeth
Allergan
Baran Robert J.
Fay Zohreh
Hoch James M.
Voet Martin A.
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