Method for reducing intraocular pressure in the mammalian eye by

Details Method for reducing intraocular pressure in the mammalian eye by Method for reducing intraocular pressure in the mammalian eye by

1995-04-28

1996-11-12

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Topical body preparation containing solid synthetic organic...

Ophthalmic preparation

514912, 514913, 514914, A61K 3174

Patent

active

055737587

ABSTRACT:
Pharmaceutical compositions and a method are disclosed for treating glaucoma and/or ocular hypertension in the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains, as the active ingredient, one or more compounds having potassium channel blocking activity. Examples of potassium channel blockers utilized in the pharmaceutical composition and method of treatment are quinine, tremogenic indole alkaloids, such as Penitrem A and paspalicine, and insect toxins such as charybdotoxin and iberiotoxin.

REFERENCES:
Fryklund et al, Acta Physiol Scand: No. 149, 1993, pp. 365-376, The effects of potassium transport inhibitors on intestinal fluid and ion transport in vivo and in vitro.
Camardo et al; Single-Channel Recording (Eds: Sakmann, B, Neher, E.); pp. 409-423; Single-Channel Analysis is Aplysia Neurons A Specific K.sup.+ Channel Is Modulated by Serotonin and Cyclic AMP.

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