Drug – bio-affecting and body treating compositions – Topical body preparation containing solid synthetic organic... – Ophthalmic preparation
Patent
1995-04-28
1996-11-12
Azpuru, Carlos
Drug, bio-affecting and body treating compositions
Topical body preparation containing solid synthetic organic...
Ophthalmic preparation
514912, 514913, 514914, A61K 3174
Patent
active
055737587
ABSTRACT:
Pharmaceutical compositions and a method are disclosed for treating glaucoma and/or ocular hypertension in the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains, as the active ingredient, one or more compounds having potassium channel blocking activity. Examples of potassium channel blockers utilized in the pharmaceutical composition and method of treatment are quinine, tremogenic indole alkaloids, such as Penitrem A and paspalicine, and insect toxins such as charybdotoxin and iberiotoxin.
REFERENCES:
Fryklund et al, Acta Physiol Scand: No. 149, 1993, pp. 365-376, The effects of potassium transport inhibitors on intestinal fluid and ion transport in vivo and in vitro.
Camardo et al; Single-Channel Recording (Eds: Sakmann, B, Neher, E.); pp. 409-423; Single-Channel Analysis is Aplysia Neurons A Specific K.sup.+ Channel Is Modulated by Serotonin and Cyclic AMP.
Adorante Joseph S.
Ruiz Guadalupe
WoldeMussie Elizabeth
Allergan
Azpuru Carlos
Baran Robert J.
Lambert Howard R.
Voet Martin A.
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