Method for reducing injury with imidazol-2-thionecarboxamides

Details Method for reducing injury with imidazol-2-thionecarboxamides Method for reducing injury with imidazol-2-thionecarboxamides

1990-06-28

1991-03-26

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514341, A61K 3144, A61K 31415

Patent

active

050029614

ABSTRACT:
Certain 2-oxo- and 2-thioxoimidazol-4-carboxamides are reported to reduce reperfusion injury which is the injury which occurs when molecular oxygen is reintroduced into an ischemic tissue. These compounds could be used to prevent much of the damage which occurs to the heart of a heart attack victim.

REFERENCES:
R. C. Smith, et al., Biochemical Pharmacology; 36(9), 1457-1460 (1987).
J. M. McCord, New England J. Med. 312(3); 159-163 (1915).

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