Method for reducing fluorescence quenching in bioassays

Details Method for reducing fluorescence quenching in bioassays Method for reducing fluorescence quenching in bioassays

2007-12-18

2007-12-18

Horlick, Kenneth R. (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007800, C435S174000, C435S183000, C436S546000, C436S800000, C514S04400A, C536S022100, C534S015000, C540S467000, C540S469000

Reexamination Certificate

active

09936563

ABSTRACT:
The invention relates to a process for reducing the fluorescence quenching caused by the measuring medium, in a fluorescence assay for an analyte using at least one fluorescent label, characterized in that a fluorescent conjugate comprising an oligonucleotide bonded to a rare-earth metal cryptate is introduced into the measuring medium.

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Li et al, “Amine-Reactive Forms . . . Energy Transfer Measurements”, 1997, Bioconjugate Chem., vol. 8, pp. 127-132.

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