Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1994-08-03
1996-08-27
O'Sullivan, Peter
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
564282, 564288, A61K 3114
Patent
active
055501630
ABSTRACT:
A method for reducing filtrate waste in a manufacturing process of a pharmaceutical product containing benzalkonium chloride as a preservative generally includes the steps of mixing the non-benzalkonium chloride components with benzalkonium chloride to formulate the product and thereafter sterilizing the product by passing same through a microfiltration membrane. In processes in which the product has a time dependent benzalkonium chloride content due to benzalkonium chloride adsorption on a microfiltration membrane, an amount of benzalkonium chloride wasted can be reduced by maintaining a selected temperature of the microfiltration membrane and the product therein.
REFERENCES:
"A Quantitative Analysis of Preservative Adsorption on Microfiltration Membranes" Brose & Henricksen; Pharmacetical Tech. pp. 64-72 Mar. 1994.
Ding Shulin
Olejnik Orest
Pallo Robert J.
Tien Walter L.
Allergan Inc.
Hackler Walter A.
O'Sullivan Peter
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