Method for reducing endogenous prostaglandin synthesis

Details Method for reducing endogenous prostaglandin synthesis Method for reducing endogenous prostaglandin synthesis

1977-11-21

1978-12-12

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424177, A61K 3514, A61K 3516, A61K 3702

Patent

active

041296486

ABSTRACT:
A high molecular weight extract of mammalian blood plasma and serum proteins of the group Cohn fraction IV, Cohn subfraction IV.sub.1, IV.sub.4 and haptoglobin, have been found to contain activity which inhibits endogenous prostaglandin synthetase. This extract is therefore of utility in treating or alleviating pathological conditions associated with excessive or unbalanced snythesis of endogenous prostaglandins, for example, in reducing bronchoconstriction or treating arthritis. For this purpose, the extract may be administered by injection, by inhalation, or topically.

REFERENCES:
patent: 3920625 (1975-11-01), Andersson et al.

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