Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-06-15
1992-04-07
Friedman, S. J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3144
Patent
active
051028875
ABSTRACT:
A method for preventing or relieving nausea and emesis associated with the use of an emesis-causing agent in warm-blooded animals comprises administering to the animal both a narcotic analgesic and a quaternary derivative of noroxymorphone prior to, simultaneously with of after administering the emesis-causing agent. A particularly preferred noroxymorphone derivative is methylnaltrexone. The method is highly effective in preventing or relieving nausea and emesis induced by anticancer drugs, and by apomorphine.
REFERENCES:
patent: 4719215 (1988-01-01), Goldberg
Krueger et al, "The Pharmacology of the Opium Alkaloids," Public Health Reports, Supplement No. 165, Part I, p. 603 and Part II, p. 817 (1940).
Janssen et al, "Chemistry and Pharmacology of Compounds Related to 4-(4-hydroxy-4-phenyl-piperidino)-butyrophenone, Part II--Inhibition of Apomorphine Vomiting in Dogs," Artzneim-Forsch, vol. 9, pp. 765-767 (1959).
ARCH Development Corporation
Friedman S. J.
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