Method for reducing blood cholesterol and/or blood triglycerides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai

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514824, A61K 3105

Patent

active

060203838

ABSTRACT:
Blood cholesterol and/or blood triglycerides are reduced in a mammalian subject by administering an effective amount of tert-butylhydroquinone or a salt thereof. The mammalian subject is preferably human. Additionally, a preparation of tert-butylhydroquinone in dosage unit form is provided to reduce blood cholesterol and/or blood triglycerides. The preparation is advantageously designed for oral administration.

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Mahley, et al., J. Lipid Research, 18:314-324, 1997.
Haliwell, B., Murcia, M.A., Chirico, S., and Aruoma, O. (1995) "Free Radicals and Antioxidants in Food and in Vivo: What They Do and How They Work", Crit. Rev. Food Sci. Nutr. 35, 7-20.
Janero, J.M. (1995) "Ischemic Heart Disease and Antioxidants: Mechanistic Aspects of Oxidative Injury and its Prevention", Crit. Rev. Food Sci., Nutr. 35, 65-81.
Partnasarathy, S., Steinberg, D., and Witztum, J.L. (1992) "The Role of Oxidized Low-Density Lipoproteins in the Pathogenesis of Atherosclerosis", Rev. Med. 43, 219-225.
Papas, A.M. (1993) "Oil-Soluble Antioxidants in Foods", Toxicology and Industrial Health 9, 123-149.
CA 111:28578, Kaplan et al. Jan. 1989.

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