Method for reducing bacterial endotoxin contamination in solutio

Details Method for reducing bacterial endotoxin contamination in solutio Method for reducing bacterial endotoxin contamination in solutio

1987-09-18

1989-02-28

Sever, Frank

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210639, 210647, 210649, B01D 1300

Patent

active

048083143

ABSTRACT:
The present invention contemplates a method of reducing a bacterial endotoxin contaminant in a biologically useful macromolecule. AN aqueous medium containing an endotoxin-contaminated macromolecule is admixed with a dialyzable surfactant, and the admixture so formed is contacted with an endotoxin sorbant to form a solid-liquid phase admixture. The contacting is maintained until the endotoxin is bound to the sorbant. The surfactant is dialyzed out of the aqueous liquid phase at a time no earlier than the maintenance step. The liquid phase containing the macromolecule is separated and recovered.

REFERENCES:
patent: 4314997 (1982-02-01), Shanbrom
patent: 4315919 (1982-02-01), Shanbrom
patent: 4380511 (1983-04-01), Mannuzza
patent: 4412985 (1983-11-01), Shanbrom
patent: 4434237 (1984-02-01), Dinarello
patent: 4541952 (1985-09-01), Hosoi et al.
patent: 4677194 (1987-06-01), Hao

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