Method for reducing atherosclerotic lesions in a mammal

Details Method for reducing atherosclerotic lesions in a mammal Method for reducing atherosclerotic lesions in a mammal

1992-10-16

1994-03-01

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

530351, A61K 3702

Patent

active

052905497

ABSTRACT:
Methods are presented for improving the lipoprotein cholesterol profile of a mammal. Methods are also presented for reducing or removing atherosclerotic lesions from a mammal that has such lesions. The methods comprise administering to the mammal a therapeutic amount of an M-CSF protein in combination with a pharmaceutically acceptable excipient.

REFERENCES:
patent: 5021239 (1991-06-01), Garnick
David H. Blankenhorn et al., "Beneficial Effects of Combined Colestipol-Niacin Therapy on Coronary Atherosclerosis and Coronary Venous Bypass Grafts" JAMA vol. 257, No. 23 pp. 3233-3240 (Jun. 19, 1987).
Alexander C. Arntzenius, et al., "Diet, Lipoproteins, and the Progression of Coronary Atherosclerois" The N.E.J. of Medicine, vol. 321 No. 13 pp. 805-810 (Mar. 28, 1985).
Barry Lewis, "Randomised Controlled Trial of the Treatment of Hyperlipidaemia on Progression of Atherosclerosis", Acta Med. Scand (Suppl.)701: pp. 53-57, (1985).
David H. Blankenhorn et al., "The Influence of Diet on the Appearance of New Lesions in Human Coronary Arteries" JAMA vol. 263 No. 12: pp. 1646-1652 (Mar. 23/30 1990).
R. G. M. Duffield et al., "Treatment of Hyperlipidaemia Retards Progression of Symptomatic Femoral Atherosclerosis" The Lancet, pp. 639-642 (Sep. 17, 1983).
Esko A. Nikkila et al., "Prevention of Progression of Coronary Atherosclerosis by Treatment of Hyperlipidaemia: A Seven Year Prospective Angiographic Study" British Medical Journal vol. 289 pp. 220-223 (Jul. 28, 1984).

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