Method for reducing aminoisophthalic acid bisamide related...

Details Method for reducing aminoisophthalic acid bisamide related... Method for reducing aminoisophthalic acid bisamide related...

2011-01-04

2011-01-04

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C424S009452

Reexamination Certificate

active

07863484

ABSTRACT:
This invention relates generally to the preparation of non-ionic X-ray contrast agents, iohexyl, ioversol, and iodixanol. It further relates to a method for improving the purity of 5-amino-N,N′-bis(2,3-dihydroxypropyl)-isophthalamide (or ABA), an intermediate in the industrial preparation of these non-ionic X-ray contrast agents. In particular, it relates to a method for significantly removing ABA monomethylester and ABA dimer from ABA by hydrolyzing ABA under a pH between about 12 to about 13 in an aqueous medium to convert ABA monomethylester to ABA monoacid, before the iodination reaction of ABA.

REFERENCES:
patent: 6274762 (2001-08-01), Malthe-Sorenssen et al.
patent: 6441235 (2002-08-01), Parady et al.
patent: RE38856 (2005-10-01), Thielking et al.
patent: 2002/0095053 (2002-07-01), Parady et al.
patent: 2004/0082811 (2004-04-01), Anelli et al.
patent: 00/29372 (2000-05-01), None

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