Method for recovering purified 100,000 molecular weight fraction

Details Method for recovering purified 100,000 molecular weight fraction Method for recovering purified 100,000 molecular weight fraction

1994-09-26

1995-07-04

Naff, David M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

424 946, 424 9461, 435814, 435815, C12N 916, A61K 3754

Patent

active

054299373

ABSTRACT:
Intestinal cell endogenous heparin mediated absorption of cholesterol or fatty acids in mammals is inhibited through the oral administration of heparin, an active heparin subfraction or heparinase. Suppression of cholesterol esterase-mediated absorption in humans can be inhibited by soluble heparin by two mechanisms, i.e. displacement of the enzyme from the intestinal cell membrane and inhibition of enzymatic activity of the displaced enzyme.

REFERENCES:
patent: 4011138 (1977-03-01), Terada et al.
patent: 5017565 (1991-05-01), Lange, III et al.
patent: 5063210 (1991-11-01), Lange, III et al.
patent: 5173408 (1992-12-01), Lange, III et al.
patent: 5352601 (1994-10-01), Lange, III et al.
Bosuer et al., Proc. Nat'l. Acad. Sci. USA, vol. 85, 7438-42, 1988.
Julien et al; Biochim. Biophys. Acta 280:215-224 (1972).
Vandermeers et al; Biochim. Biophys. Acta 370: 257-268 (1974).
Matsumura et al; J. Biol. Chem. 251 (20): 6267-6273 (1976).
Breuter et al; Biochim. Biophys. Acta 530: 112-123 (1978).
Lombardo et al; Biochim. Biophys. Acta 527: 142-149 (1978).
Tuhackova et al; Biochim. Biophys. Acta 617: 439-445 (1980).
Tsujita et al; Biochim. Biophys. Acta 715: 181-188 (1982).
Durham, III et al; J. Biol. Chem. 259 (12): 7433-7438 (1984).
Treadwell et al., in Handbook of Physiology, Section 6, vol. III (1968) pp. 1407-1438.
Brockerhoff et al., in Lipolytic Enzymes, Chp. 5 (Academic Press, 1974) pp. 176-193.
Rudd et al., in Lipases (Elsevier, N.Y., 1984) pp. 185-204.
Calame et al., (1975) Arch. Bioch. Biophys. 168: 57-65.
Van den Bosch et al., (1973) Biochem. Biophys. Acta. 296: 94-104.
Momsen et al., (1977) Biochem. Biophys. Acta. 486: 103-113.
Guy et al., (1981) Eur. J. Biochem. 117: 457-460.
Casdorph H. R., in Lipid Pharmocology (Academic Press, 1976) pp. 221-256.
Ayotte and Perlin, (1986) Carbohydrate Res. 145: 267-277.
Cardin et al., (1984) Thrombosis Res. 34: 541-550.

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