Method for recovering optically active tryptophan

Details Method for recovering optically active tryptophan Method for recovering optically active tryptophan

1991-07-31

1994-07-12

Straub, Gary P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

23298, 548497, 548499, C07D20920, C12P 1322

Patent

active

053290143

ABSTRACT:
Optically active tryptophan of high purity can be obtained in high yields from a tryptophan fermentation broth, using crystallization of optically active tryptophan hydrochloride in combination with concurrent neutralization crystallization. According to the present invention, optically active tryptophan from a tryptophan containing fermentation broth, is carried out by (a) removing cells from the fermentation broth, adding hydrochloric acid, or a mixture of hydrochloric acid and an inorganic salt which contains chloride ions, to the cell-free broth to effect crystallization, (b) separating optically active tryptophan hydrochloride, (c) dissolving the optically active tryptophan hydrochloride, and (d) subjecting the resulting solution and an alkali solution to concurrent neutralization crystallization, maintaining a pH of the crystallization solution in the range of from 3 to 8.

REFERENCES:
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patent: 4588818 (1986-05-01), Kaneko et al.
patent: 4820825 (1989-04-01), Ootani et al.
patent: 5070208 (1991-12-01), Yarita et al.
Sienko, M. J. et al. "Chemistry", 2nd ed. McGraw-Hill: New York (1961), p. 346.

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