Method for recovering myeloperoxidase and pharmaceutical composi

Details Method for recovering myeloperoxidase and pharmaceutical composi Method for recovering myeloperoxidase and pharmaceutical composi

1980-08-20

1981-12-15

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

435816, 424 94, C12N 908

Patent

active

043060250

ABSTRACT:
Myeloperoxidase can be separated and recovered from a supernatant liquid of an aqueous dispersion of a disintegration product of human myelogenous leukocytes, which dispersion has been admixed with at least one member selected from the group consisting of manganese salts and protamine sulfate. The recovered myeloperoxidase in combination with an alkali metal halide can be used as a pharmaceutical composition effective against microorganisms deficient or diminished in catalase synthesizing activity.

REFERENCES:
Methods in Enzymology, vol. 2, pp. 794-801, (1955).
Chemical Abstracts, 94:134695e, (1981).
Advances in Enzymology, vol. 3, pp. 137-148, (1943).

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