Method for recovering .alpha.-L-aspartyl-L-phenylalanine methyl

Details Method for recovering .alpha.-L-aspartyl-L-phenylalanine methyl Method for recovering .alpha.-L-aspartyl-L-phenylalanine methyl

1987-06-03

1989-04-18

Gray, Bruce D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C10352

Patent

active

048229075

ABSTRACT:
A process for recovering .alpha.-L-aspartyl-L-phenylalanine methyl ester from a solution containing various methyl ester or demethylated derivatives of .alpha.-L-aspartyl-L-phenylalanine methyl ester and chloride ions is disclosed. This process uses a reverse osmosis membrane having a specific chloride inhibition rate to desalt and concentrate a solution containing a specified ratio of .delta.-L-aspartyl-L-phenylalanine methyl ester to its derivatives until a specific weight ratio of organic chloride ion to the sum of .alpha.-L-aspartyl-L-phenylalanine methyl ester and its derivatives is obtained. This desalted and concentrated solution is then contacted with an aqueous solvent containing methanol and hydrochloride acid to recover high yields of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride.

REFERENCES:
patent: 3544455 (1970-12-01), Adams et al.
patent: 3798207 (1974-03-01), Ariyoshi et al.
patent: 3833554 (1974-09-01), Ariyoshi et al.
patent: 4309341 (1982-01-01), Kubo et al.
patent: 4601829 (1986-07-01), Kaneko et al.

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