Method for reconstructing the distribution of fluorophores...

Details Method for reconstructing the distribution of fluorophores... Method for reconstructing the distribution of fluorophores...

2011-06-21

2011-06-21

Lyons, Michael A (Department: 2877)

Optics: measuring and testing

By dispersed light spectroscopy

With sample excitation

Reexamination Certificate

active

07965389

ABSTRACT:
The method enables a non-homogeneous diffusing object to be examined by illuminating the object with a continuous light by means of a light source. It previously comprises reconstruction of the three-dimensional spatial mapping of an attenuation variable representative of the diffusion and absorption non-homogeneities of the object, by resolving a diffusion equationin-line-formulae description="In-line Formulae" end="lead"?∇2F({right arrow over (r)}S, {right arrow over (r)})−k′2({right arrow over (r)})F({right arrow over (r)}S, {right arrow over (r)})=ASδ({right arrow over (r)}−{right arrow over (r)}S).in-line-formulae description="In-line Formulae" end="tail"?In the diffusion equation, ASis a constant, {right arrow over (r)} the spatial coordinate of any point of the mesh of a volume at least partially containing the object, and {right arrow over (r)}Sthe spatial coordinate of the light source. The transfer functions of an equation used for reconstructing the distribution of fluorophores integrate the attenuation variable reconstituted in this way.

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