Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2011-01-18
2011-01-18
Chen, Shin-Lin (Department: 1632)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C536S023500, C530S350000
Reexamination Certificate
active
07871817
ABSTRACT:
The invention relates to the rational mutagenesis of polypeptides of α/β T-cell receptors that mediate an oncogen-specific T-cell response, nucleic acids encoding these and their use in the therapy, diagnosis and/or prevention of cancerous diseases. The invention further relates to a T-cell response-mediating MDM2-protein-specific α/β T-cell receptor, which has been rationally mutated by means of the method according to the present invention, and the uses thereof.
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Matthias Theobald
Voss Ralf-Holger
Chen Shin-Lin
Johannes Gutenberg-Universitat Mainz
Saliwanchik Lloyd & Saliwanchik
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