Surgery – Means for introducing or removing material from body for... – Infrared – visible light – ultraviolet – x-ray or electrical...
Patent
1993-07-23
1996-08-20
Buiz, Michael Powell
Surgery
Means for introducing or removing material from body for...
Infrared, visible light, ultraviolet, x-ray or electrical...
6048901, A61M 3700
Patent
active
055474675
ABSTRACT:
A method is disclosed for treating tissue in response to a stimulus generated by the tissue. In one embodiment, the method transdermally treats an organism in response to a stimulus. In this embodiment, the medication is applied to epidermis of the organism, and the epidermis is electroporated in response to a stimulus, whereby the medication passes through the epidermis at a rate sufficient to alter the stimulus, thereby transdermally treating the organism. In another embodiment, the method measures a blood component content of blood. A portion of epidermis is electroporated to cause an aqueous fluid to be directed through an electroporated epidermis to a surface of the epidermis. Thereafter, the blood component content of the aqueous fluid is measured for correlation with a known aqueous fluid blood component content associated with a known concentration of blood component in the blood. The blood component concentration of the blood can thereby be measured. In still another embodiment, the method includes directing a medication to the tissue which can alter the stimulus when the tissue is electroporated, and electroporating the tissue in response to a stimulus, whereby the medication passes through the tissue in an amount sufficient to alter the stimulus, thereby treating the organism.
REFERENCES:
patent: 578611 (1897-03-01), Rively
patent: 3078850 (1963-02-01), Schein et al.
patent: 3614955 (1971-10-01), Mirowski
patent: 3680544 (1972-08-01), Shinnick et al.
patent: 4411648 (1983-10-01), Davis et al.
patent: 4784737 (1988-11-01), Ray et al.
patent: 4955378 (1990-09-01), Grasso
patent: 4979948 (1990-12-01), Geddes et al.
patent: 5007995 (1991-04-01), Takahashi et al.
patent: 5047007 (1991-09-01), McNichols et al.
patent: 5098843 (1992-03-01), Calvin
Prausnitz, et al., "Transtissue Molecular Transport Due to Electroporation of Skin," Electricity and Magnetism in Biology and Medicine, 122-124 (1993).
Prausnitz, et al., "Transdermal Drug Delivery by Electroporation," Proceed. Intem. Symp. Control. Rel. Bioact. Mater., 19:232-233 (1992).
Mir, et al., "Electrochemotherapy: A New Antitumor Treatment Using Electric Pulses," Electricity and Magnetism in Biology and Medicine, 119-121 (1993).
Mir, et al., "L'electrochimiotherapie, un Nouveau Traitement Antitumoral: Premier Essai Clinique," C.R. Acad. Sci. Paris, 313 Serie III: 613-618, (1991).
Mir, et al., "Electrochemotherapy Tumor Treatment is Improved by Interleukin-2 Stimulation of the Host's Defenses," Eur. Cytokine Netw., 3(3):331-334, (1992).
Belehradek, Jr. et al., "Electrochemotherapy of Spontaneous Mammary Tumours in Mice," Eur. Cancer, 27(1):73-76, (1991).
Okino, et al., "Optimal Electric Conditions in Electrical Impulse Chemotherapy," Jpn. J. Cancer Res., 83:1095-1101, (1992).
Okino et al., "The Effects of a Single High Voltage Electrical Stimulation With an Anticancer Drug on in vivo Growing Malignant Tumors," Jpn. J. of Surgery, 20(2):197-204, (1990).
R. Heller, "Incorporation of Individual Cells Into Intact Tissue by Electrofusion," Electricity and Magnetism in Biology and Med., 115-117, (1993).
Heller, et al., "Development of Cell-Tissue Electrofusion for Biological Applications," Guide to Electroporation and Electrofusion, 393-410, (1992).
Mir et al., "Improvement of Anticancer Electrochemotherapy," Proceedings of the American Association for Cancer Research, 30:571, Abstract No. 2274, (1989).
Mir et al., "Pharmacological Applications of Electropermeabilization of Living Cells," Lab. de Biochimie-Enzymologie, Institute Gustave-Roussy 94805 Villejuif Cadex--France.
Mir et al., "Potentiation of Bleomycin by Local Electric Pulses: Experimental Anticancer Electrochemotherapy," Proceedings of the American Association for Cancer Research, 30:440, Abstract No. 2612, (1990).
Mir et al., "Electrochemotherapy Potentiation of Antitumor Effect of Bleomycin by Local Electric Pulses," Eur. F Cancer, 27(1):68-72 (1991).
Okino et al., "Effects of a High-Voltage Electrical Impulse and an Anticancer Drug on In Vivo Growing Tumors," Jpn. J. Cancer Res., 78(12):1319-1312 (1987).
Heroux et al., "Assessment of Trauma in Tissue by Electrical Impedance Measurements." In C. T. Brighton and S. R. Pollack (Ed.), Electromagnetics in Biology and Medicine (SF: San Francisco Press, Inc.), pp. 215-221 (1991).
Bhatt et al., "Rhabdomyolysis Due to Pulsed Electric Fields," Plastic and Reconstructive Surgery, 86(1):1-11 (1990).
Heller et al., "Transfer of Human Membrane Surface Components by Incorporating Human Cells into Intact Animal Tissue by Cell Tissue Electrofusion In Vivo," Biochimica et Biophysica Acta., 1024:185-188 (1990).
Titomirov et al., "In Vivo Electroporation and Stable Transformation of Skin Cells of Newborn Mice by Plasmid DNA," Biochimica et Biophysica Acta., 1088:131-134 (1991).
Okino, et al., "Intracellar Bleomycin Concentration and Histrological Examination in Electrical Impulse Chemotherapy," J. of Japan Soc. for Cancer Therapy, 22(8):337 (1987).
Kanesada, et al., "Anticancer Effects of Electical Impulse Chemotherapy for the Primary and Metastatic Foci of Lewis Lung Carcinoma," J. of Japan Soc. for Cancer Therapy, 22(8):338 (1987).
Okino, et al., "Proceedings of the Japanese Cancer Association 46th Annual Meeting, Sep. 7-9, 1987," Japan J. of Cancer Research, 46:420 (1987).
Tatsuka et al., "An Improved Method of Electroporation for Introducing Biological Active Foreign Genes into Cultured Mammalian Cells," Experimental Cells Research, 178:154-162 (1988).
Melvik et al., "Increase in Cis-Dichloroldiammineplatinum (II) Cytotoxicity upon Reversible Electropermeabilization of the Plasma Membrane in Cultured Human NHIK 3025 Cells," Eur. J. Cancer Clin. Oncol., 22(12):1530 (1986).
Kubota, et al., "Toxicity and Metabolism of Ara-CTP Injected into Cells by Electroporation," Proc. Amer. Assoc. Cancer Res., 31:397, Abstract 2356, (1990).
Duvanel et al., "New Technique to Perform Local Anesthesia: Pulsed Iontophoresis," Dermatology, 177(1):30 (1988).
Orlowski et al., "Transient Electropermeabilization of Cells in Culture: Increase of the Cytotoxicity of Anticancer Drugs," Biochem. Pharmacol., 37(24):4727-4733 (1988).
Tovar et al., "Electroporation and Recovery of Cardiac Cell Membrane with Rectangular Voltage Pulses," Am. J. Physiol. 263 (Heart Circ. Physiol. 32):H1128-H1136 (1992).
Grasso et al., "Electrofusion of Individual Animal Cells Directly to Intact Corneal Epithelial Tissue," Biochimica et Biophysica Acta, 980:9-14 (1989) .
Langer Robert S.
Pliquett Uwe
Prausnitz Mark R.
Weaver James C.
Buiz Michael Powell
Massachusettes Institute of Technology
Mulcare Nancy
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