Method for rapid in vivo assessment of intravenous irritation of

Details Method for rapid in vivo assessment of intravenous irritation of Method for rapid in vivo assessment of intravenous irritation of

1991-06-20

1993-11-30

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

128630, G01N 3315

Patent

active

052663019

ABSTRACT:
The present invention is a method for rapid in vivo assessment of intravenous irritation of pharmaceutical compositions. The assessment of the vascular irritability of new pharmaceutical agents, vehicles and their pharmaceutical compositions has traditionally been limited to histological characterization of postinfusion damage. These studies utilized about 15 conscious animals and required about two weeks to complete. The method of the present invention in contrast utilizes fewer animals and can be completed in as short as only about 2-4 hr. In addition the direct observation is contemporaneous with the infusion and utilized a central vein.

REFERENCES:
Morita et al. "Intravenous Irritation Test of DI-63 in Rabbits" PreClin. Rep. 13(1) 1987 (Abstract).
Nomura et al. "Intravenous Irritation Test of Naftidrofuryl LS-121 LS-121 in Retroauricular Veins of Rabbits" PreClin. Rep. 11(2) 1985 Abstract.

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