Method for radiolabeling proteins

Details Method for radiolabeling proteins Method for radiolabeling proteins

1988-04-01

1991-10-29

Kepplinger, Esther L.

Chemistry: analytical and immunological testing

Involving producing or treating antigen or hapten

Producing labeled antigens

436544, 436804, 530402, 530403, 530404, 530406, 530408, 530412, 530417, 530387, 530388, 424 11, G01N 33534, C07K 300, C07K 1500, A61K 4300

Patent

active

050616412

ABSTRACT:
A protein containing at least one pendant sulfhydryl group is directly radiolabeled with a radiometal which binds tightly to sulfhydryl groups, using one or more pendant sulfhydral groups on the protein as endogenous ligands and optionally using an exogenous ligand which binds tightly to the radiometal ion to further stabilize the chelate.

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patent: 4693884 (1987-09-01), Kleiner et al.
patent: 4732864 (1988-03-01), Tolman
Petit et al., Cancer Research, vol. 43, pp. 3043-3045 (Aug. 1980).
Hosain, World Congress on Medical Physics and Biomedical Engineering (1988).
Rhodes et al., International Symposium, Labeled & Unlabeled Antibody in Cancer Diagnosis & Therapy, 2 (b), 217 (1985).
Vuk-Pavlovic et al., Biochemistry (18/7: 1125-1129) (4-1-79).
Steiner et al., Biochemistry 10, 4725-4739 (1971).
Proceedings of the 34th Annual Meeting, No. 695, p. 721, vol. 28, #4 (4/87).

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