Method for radiolabeling monovalent antibody fragments

Details Method for radiolabeling monovalent antibody fragments Method for radiolabeling monovalent antibody fragments

1992-12-08

1994-08-02

Elliott, George C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

436547, 436548, 5303871, 5303881, 5303913, 530404, C07K 1528

Patent

active

053347080

ABSTRACT:
A method for radiolabeling a monovalent Fab or Fab' antibody fragment which comprises the steps of cleaving a divalent F(ab).sub.2 or F(ab').sub.2 antibody fragment using sulfite or meta-bisulfite ions to produce a monovalent fragment having a free sulfhydryl group, and contacting the monovalent fragment with a cation of a metallic radionuclide which binds to sulfhydryl groups, without removing excess sulfite or metabisulfite.

REFERENCES:
patent: 4059571 (1977-11-01), Tomibe et al.
patent: 4638049 (1987-01-01), Masuho et al.
patent: 5011676 (1991-04-01), Thakur
patent: 5061641 (1991-10-01), Schochat et al.

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