Method for radiolabeling antibody fragments

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...

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424 169, 5303913, 5303915, A61K 39395

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active

055143636

ABSTRACT:
A protein containing at least one pendant sulfhydryl group is directly radiolabeled with a radiometal which binds tightly to sulfhydryl groups, using one or more pendant sulfhydryl groups on the protein as endogenous ligands and optionally using an exogenous ligand which binds tightly to the radiometal ion to further stabilize the chelate.

REFERENCES:
patent: 4652440 (1987-03-01), Paik et al.
patent: 4877868 (1989-10-01), Reno et al.
patent: 5053493 (1991-10-01), Pak et al.
patent: 5061641 (1991-10-01), Shochat et al.
patent: 5078985 (1992-01-01), Rhodes
patent: 5102990 (1992-07-01), Rhodes
patent: 5128119 (1992-07-01), Griffiths et al.
patent: 5328679 (1994-07-01), Hansen et al.
Nuclear Medicine, 21:59-62, (1980).
Pettit et al (1980) Cancer Res. 40:3043-3045.
Pettit et al, "Improved Protein Labeling by Stannous Tartrate Reduction of Pertechnetate," The Journal of Nuclear Medicine, 21:59-62, (1980).

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