Method for racemization of (S)-(+)- and...

Details Method for racemization of (S)-(+)- and... Method for racemization of (S)-(+)- and...

2007-03-13

2007-03-13

Coleman, Brenda (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

10842726

ABSTRACT:
A high-yielding method and a useful intermediate, 10-chloro-10,11-dihydro-5H-dibenz/b,f/azepine-5-carboxamide (VII) is disclosed. Also disclosed are methods for the racemization of optically pure or optically enriched mixtures of (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (I) and (R)-(−)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (II) to racemic (±)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (III).

REFERENCES:
patent: 1 495 176 (1977-12-01), None
patent: 56073066 (1981-06-01), None
patent: WO 02/092572 (2002-11-01), None
Great Britain Search Report, GB 0310856.0; Sep. 23, 2003; 3 pages.
Schutz, H. et al.;The metabolism of C-oxcarbazepine inman; Xenobiotica; vol. 16; 1986; pp. 769-778.
Benes, J. et al.;Anticonvulsant and Sodium Channel-Blocking Properties of Novel 10,11-Dihydro-5H-dibenz'b,flazepine-5-carboxamide Derivatives; J. Med. Chem.; vol. 42; 1999; pp. 2582-2587.

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