Chemistry: analytical and immunological testing – Optical result
Reexamination Certificate
2001-02-09
2008-07-08
Alexander, Lyle A (Department: 1797)
Chemistry: analytical and immunological testing
Optical result
C422S082050
Reexamination Certificate
active
07396684
ABSTRACT:
The invention relates to a method for quantitatively and/or qualitatively detecting layer thicknesses of biological or chemical molecules by means of ellipsometric measurements. Said molecules are deposited on at least one metal layer by virtue of interactions with a gaseous or liquid medium, whereby said metal layer is provided with an immobilisation layer. A method that can be carried out quickly is provided by including the surface plasmon resonance. Said method is provided with a significantly greater detection sensitivity and can be used not only for qualitatively detecting layers. According to the inventive method, the angle of incidence and/or the frequency of the electromagnetic radiation which is used for the ellipsometric measurements is/are adjusted in such a way that a surface plasmon resonance is produced in the metal layer. The detection sensitivity (δ cos Δ)/(thickness of the layer to be detected) is adjusted by means of the thickness of the metal layer.
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Berger Svend
Ehrfeld Wolfgang
Limburg Bernd
Pommereau Antje
Westphal Peter
Alexander Lyle A
Hudak, Shunk & Farine Co. LPA
Institut fur Mikrotechnik Mainz GmbH
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