Chemistry: analytical and immunological testing – Peptide – protein or amino acid – Amino acid or sequencing procedure
Reexamination Certificate
2001-06-07
2004-10-05
Russel, Jeffrey Edwin (Department: 1654)
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
Amino acid or sequencing procedure
C436S090000, C530S345000, C530S409000, C548S222000
Reexamination Certificate
active
06800486
ABSTRACT:
FIELD OF THE INVENTION
The present invention is directed to methods for the quantitative determination of amino acids.
SUMMARY OF THE INVENTION
The present invention is directed to a novel method for derivatizing amino acids or peptides, which method comprises reacting an amino acid or peptide with a fluorescent benzoxazole derivative, such as 2-chlorobenzoxazole.
The present invention is also directed to a method of detecting, qualitatively and quantitatively, amino acids and peptides, which method comprises reacting an amino acid or peptide with 2-chlorobenzoxazole and detecting the resultant derivative by a suitable method, such as UV or fluorescence methods.
The present invention also relates to the novel benzoxazole- amino acid derivatives, N-(2-benzoxazolyl) amino acids as described herein.
REFERENCES:
patent: 4814459 (1989-03-01), Boesenberg et al.
patent: 5296486 (1994-03-01), Lazer et al.
Advani, et al. Potential Antineoplastic Agents: N-(2-Benzoxazolyl)amino Acid Esters. Journal of Pharmaceutical Sciences. Oct. 1968, vol. 57, No. 10, pp. 1693-1696, especially Table I, p. 1695, col. 1, paragraph bridging pp. 1695 and 1696.
Langguth et al. Fluorescence Assay . . . Journal of Chromatography. 1990, vol. 528, pp. 55-64.
Kinzig Charles M.
McCarthy Mary E.
Russel Jeffrey Edwin
Simon Soma G.
SmithKline Beecham Corporation
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